NU 9056

Research use only, not for human use.

NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 μM. NU 9056 blocks DNA damage response and inhibits protein acetylation in prostate cancer cell lines.

NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an of 2 μM. NU9056 shows >16-fold selectivity for Tip60 over PCAF, p300 and GCN5. NU9056 induces apoptosis of prostate cancer cells.

Apoptosis Analysis Cell Line:LNCaP cellsConcentration:17 μM, 24 μM, 36 μM Incubation Time:24 hours, 48 hours, 72 hours, 96 hours Result:Induced apoptosis via activation of caspase 3 and caspase 9 in a concentration- and time-dependent manner. Western Blot Analysis Cell Line:LNCaP cells Concentration:2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM Incubation Time:2 hours Result:Resulted in decreased levels of acetylated histone H4K16, H3K14 and H4K8, targets for Tip60-mediated acetylation.

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Others

Other Targets

Histone Acetyltransferase

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1450644-28-6

232.37

C6H4N2S4

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (537.94 mM; Ultrasonic )

S(Sc1ccns1)c1ccns1

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(-20℃)

With Ice Pack

≥ 2 years